原创力文档2011 german escherichia coli o104h4 outbreak whole-genome phylogeny without alignment2011年德国大肠杆菌疫情o104h4全基因组发展史没有对齐.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
2011 german escherichia coli o104h4 outbreak whole-genome phylogeny without alignment2011年德国大肠杆菌疫情o104h4全基因组发展史没有对齐
2011 German Escherichia coli O104:H4 outbreak:
whole-genome phylogeny without alignment
Cheung et al.
Cheung et al. BMC Research Notes 2011, 4:533
/1756-0500/4/533 (13 December 2011)
Cheung et al. BMC Research Notes 2011, 4:533
/1756-0500/4/533
SHORT REPORT Open Access
2011 German Escherichia coli O104:H4 outbreak:
whole-genome phylogeny without alignment
*
Man-Kit Cheung, Lei Li, Wenyan Nong and Hoi-Shan Kwan
Abstract
Background: A large-scale Escherichia coli O104:H4 outbreak occurred in Germany from May to July 2011, causing
numerous cases of hemolytic-uremic syndrome (HUS) and deaths. Genomes of ten outbreak isolates and a
historical O104:H4 strain isolated in 2001 were sequenced using different new generation sequencing platforms.
Phylogenetic analyses were performed using various approaches which either are not genome-wide or may be
subject to errors due to poor sequence alignment. Also, detailed pathogenicity analyses on the 2001 strain were
not available.
Findings: We reconstructed the phylogeny of E. coli using the genome-wide and alignment-free feature frequency
profile method and revealed the 2001 strain to be the closest relative to the 2011 outbreak strain among all
available E. coli strains at present and confirmed findings from previous alignment-based phylogenetic studies that
the HUS-causing O104:H4 strains are more closely related to typical enteroaggregative E. coli (EAEC) than to
enterohemorrhagic E. coli. Detailed re-examination of pathogenicity-related virulence factors and secreted proteins
showed that the 2001 strain possesses virulence factors shared between typical EAEC and the 2011 outbreak st
您可能关注的文档
- 1,2-propanediol-trehalose mixture as a potent quantitative real-time pcr enhancer1,2-propanediol-trehalose混合物作为一个有效的定量实时pcr增强剂.pdf
- 2r and remodeling of vertebrate signal transduction engine2 r和装修脊椎动物信号转导引擎.pdf
- 1,1-bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice1、一号乙(3 ' -indolyl)1 -(p-biphenyl)甲烷抑制官腔无胸腺的裸体小鼠的乳腺癌的增长.pdf
- 2db a proteomics database for storage, analysis, presentation, and retrieval of information from mass spectrometric experiments2 db蛋白质组学数据库的存储、分析、演示和检索信息的质谱实验.pdf
- 3' tag digital gene expression profiling of human brain and universal reference rna using illumina genome analyzer3 '标签的数字基因表达分析人类大脑和普遍使用illumina公司参考rna基因组分析仪.pdf
- 3dmolnavi a web-based retrieval and navigation tool for flexible molecular shape comparison3 dmolnavi网络检索和导航工具,灵活的分子形状的比较.pdf
- 3d nuclear organization of telomeres in the hodgkin cell lines u-ho1 and u-ho1-ptpn1 ptpn1 expression prevents the formation of very short telomeres including t-stumps3 d核组织的端粒霍奇金细胞系u-ho1和u-ho1-ptpn1 ptpn1表达式包括t-stumps防止短端粒的形成.pdf
- 3d collagen type i matrix inhibits the antimigratory effect of doxorubicin三维胶原蛋白i型矩阵抑制antimigratory阿霉素的影响.pdf
- 2the role of controlling behaviour in intimate partner violence and its health effects a population based study from rural vietnam2控制亲密伴侣暴力行为的作用及其健康影响基于人口的研究从农村越南.pdf
- 2-aminoacetophenone as a potential breath biomarker for pseudomonas aeruginosa in the cystic fibrosis lung2-aminoacetophenone呼吸作为一个潜在的生物标志物的铜绿假单胞菌肺囊性纤维化.pdf
- 454 pyrosequencing based transcriptome analysis of zygaena filipendulae with focus on genes involved in biosynthesis of cyanogenic glucosides454焦磷酸测序转录组分析zygaena filipendulae关注参与生物合成基因的生氰糖甙.pdf
- a 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice a non-interventional prospective study in 1273 patients的6个配方leuprolide醋酸是安全的和有效的在日常临床实践non-interventional前瞻性研究1273例.pdf
- a 7 gene expression score predicts for radiation response in cancer cervix7基因表达评分预测辐射反应癌症子宫颈.pdf
- a 10 year study of the cause of death in children under 15 years in manhi？a, mozambique10年研究以下儿童死因的15年manhi ,莫桑比克.pdf
- a 6-months assessment of the alcohol-related clinical burden at emergency rooms (ers) in 11 acute care hospitals of an urban area in germany持续的评估与酒精有关的临床负担在11急症护理医院急诊室(ers)的市区在德国.pdf
- a ~35 kda polypeptide from insect cells binds to yeast acs like elements in the presence of atp从昆虫细胞~ 35 kda多肽结合酵母acs相似元素的atp.pdf
- a 6-gene signature identifies four molecular subgroups of neuroblastoma6-gene签名识别四个神经母细胞瘤的分子子组.pdf
- 93rd annual meeting of the american association for cancer research, san francisco, ca, usa, 6-10 april 2002第93届会议的美国癌症研究协会,旧金山,美国,2002年4月6 - 10.pdf
- a bac library of the sp80-3280 sugarcane variety (saccharum sp.) and its inferred microsynteny with the sorghum genome甘蔗品种的bac文库sp80 - 3280(蔗糖sp)及其推断microsynteny高粱基因组.pdf
- a 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells96 -高通量杆状病毒一代好格式,快速的效价和生产重组蛋白在昆虫和哺乳动物细胞.pdf
文档评论（0）