a computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue可计算细胞压力十几肺和心血管组织的网络模型.pdfVIP

Schlage et al. BMC Systems Biology 2011, 5:168 /1752-0509/5/168 METHODOLOGY ARTICLE Open Access A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue 1 2 1 2 3 2 Walter K Schlage , Jurjen W Westra , Stephan Gebel , Natalie L Catlett , Carole Mathis , Brian P Frushour , 1 2 3 2 3 2 Arnd Hengstermann , Aaron Van Hooser , Carine Poussin , Ben Wong , Michael Lietz , Jennifer Park , 2 3 3 3* 2 David Drubin , Emilija Veljkovic , Manuel C Peitsch , Julia Hoeng and Renee Deehan Abstract Background: Humans and other organisms are equipped with a set of responses that can prevent damage from exposure to a multitude of endogenous and environmental stressors. If these stress responses are overwhelmed, this can result in pathogenesis of diseases, which is reflected by an increased development of, e.g., pulmonary and cardiac diseases in humans exposed to chronic levels of environmental stress, including inhaled cigarette smoke (CS). Systems biology data sets (e.g., transcriptomics, phosphoproteomics, metabolomics) could enable comprehensive investigation of the biological impact of these stressors. However, detailed mechanistic networks are needed to determine which specific pathways are activated in response to different stressors and to drive the qualitative and eventually quantitative assessment of these data. A current limiting step in this process is the availability of detailed mechanistic networks that can be used as an analytical substrate. Results: W