a copula method for modeling directional dependence of genes一种介体方法建模定向依赖的基因.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A copula method for modeling directional dependence of genes 1 2 1 3 Jong-Min Kim , Yoon-Sung Jung , Engin A Sungur , Kap-Hoon Han , 4 5 Changyi Park* and Insuk Sohn Address: 1Division of Science and Mathematics, University of Minnesota, Morris, MN, 56267, USA, 2Department of Statistics, Kansas State University, Manhattan, Kansas, 66506, USA, 3Department of Pharmaceutical Engineering, Woosuk University, Wanju, Jeonbuk, 565-701, Republic of Korea, 4Department of Statistics, University of Seoul, Seoul 136-743, Republic of Korea and 5Department of Statistics, Korea University, Seoul 136-701, Republic of Korea Email: Jong-Min Kim - jongmink@; Yoon-Sung Jung - ysjung72@; Engin A Sungur - sungurea@; Kap- Hoon Han - khhan@woosuk.ac.kr; Changyi Park* - park463@uos.ac.kr; Insuk Sohn - sis46@korea.ac.kr * Corresponding author Published: 1 May 2008 Received: 23 November 2007 Accepted: 1 May 2008 BMC Bioinformatics 2008, 9:225 doi:10.1186/1471-2105-9-225 This article is available from: /1471-2105/9/225 © 2008 Kim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Genes interact with