a comprehensive curated resource for follicle stimulating hormone signaling促卵泡激素信号的综合策划资源.pdfVIP

Telikicherla et al. BMC Research Notes 2011, 4:408 /1756-0500/4/408 SHORT REPORT Open Access A comprehensive curated resource for follicle stimulating hormone signaling 1,2 3 1,4 1,5 1,2 Deepthi Telikicherla , Aditi Ambekar , Shyam Mohan Palapetta , Sutopa B Dwivedi , Rajesh Raju , 1,6 1,4,6 2 1,2,7 1,6,8 Jyoti Sharma , TS Keshava Prasad , YL Ramachandra , S Sujatha Mohan , Jagadeesha Maharudraiah , Srabani Mukherjee3 and Akhilesh Pandey9,10,11,12* Abstract Background: Follicle stimulating hormone (FSH) is an important hormone responsible for growth, maturation and function of the human reproductive system. FSH regulates the synthesis of steroid hormones such as estrogen and progesterone, proliferation and maturation of follicles in the ovary and spermatogenesis in the testes. FSH is a glycoprotein heterodimer that binds and acts through the FSH receptor, a G-protein coupled receptor. Although online pathway repositories provide information about G-protein coupled receptor mediated signal transduction, the signaling events initiated specifically by FSH are not cataloged in any public database in a detailed fashion. Findings: We performed comprehensive curation of the published literature to identify the components of FSH signaling pathway and the molecular interactions that occur upon FSH receptor activation. Our effort yielded 64 reactions comprising 35 enzyme-substrate reactions, 11 molecular association events, 11 activation events and 7 protein translocation events that occur in response to FSH receptor activation. We