原创力文档a comprehensive analysis of non-sequential alignments between all protein structures综合分析的非时序的所有蛋白质结构之间对齐.pdfVIP
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a comprehensive analysis of non-sequential alignments between all protein structures综合分析的非时序的所有蛋白质结构之间对齐
BMC Structural Biology BioMed Central
Research article Open Access
A comprehensive analysis of non-sequential alignments between all
protein structures
Alexej Abyzov and Valentin A Ilyin*
Address: Department of Biology, Northeastern University 360 Huntington Avenue, Boston, MA 02115, USA
Email: Alexej Abyzov - abyzov@; Valentin A Ilyin* - ilyin@
* Corresponding author
Published: 16 November 2007 Received: 14 May 2007
Accepted: 16 November 2007
BMC Structural Biology 2007, 7:78 doi:10.1186/1472-6807-7-78
This article is available from: /1472-6807/7/78
© 2007 Abyzov and Ilyin; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The majority of relations between proteins can be represented as a conventional
sequential alignment. Nevertheless, unusual non-sequential alignments with different connectivity
of the aligned fragments in compared proteins have been reported by many researchers. It is
interesting to understand those non-sequential alignments; are they unique, sporadic cases or they
occur frequently; do they belong to a few specific folds or spread among many different folds, as a
common feature of protein structure. We present here a comprehensive large-scale study of non-
sequential alignment
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