大豆异黄酮对高脂血症大鼠脂类代谢作用实验探究.docVIP

大豆异黄酮对高脂血症大鼠脂类代谢作用实验探究 　 作者：马克龙 那莎 汪远金 许冠荪 毕业论文 【摘要】 　　目的：探讨大豆异黄酮（Soy isoflavones,SI）对实验性高脂血症大鼠血脂水平及体内过氧化状态的 影响 。 方法 ：用高脂饲料喂养Wistar大鼠，建立高脂血症大鼠模型，随后利用SI进行干预，实验9周腹主动脉取血，检测实验大鼠血清有关脂类代谢指标的变化情况。结果：高剂量SI显著抑制高脂饲料所致的血脂水平的升高（P＜0.01），促进apoAI的合成，抑制apoB100的合成（P＜0.01），SI对实验性高脂血症大鼠体内脂质过氧化物升高具有拮抗作用，并可提高谷胱甘肽过氧化物酶（glutathione peroxidase,GSH-Px）、超氧化物歧化酶（superoxide dismutase,SOD）的抗氧化活性（P＜0.05～P＜0.01）。结论：SI对有明显高脂血症的作用，并能改善高脂所致体内异常的过氧化状态，保持肌体免遭过氧化损伤。 毕业论文 【关键词】 大豆异黄酮 高脂血症大鼠 脂类代谢 脂质过氧化 　　 The experimental study of the effect of soybean isoflavones on hyperlipemia in rats 论文代写 　　【Abstract】Objective:To investigate the effect of soy isoflavones(SI)on the metabolism of fat level blood and lipid peroxides in hyperlipemia rats.Methods:According to serum cholesterol level ,sixty wistar rats were randomly divided into six groups:normal control group,hypercholesterolemia control group,simvastatin control group and three SI treatment groups.Rats were fed with high cholesterol food except NC group rats.Making the models of hyperlipemia rats.then,SI 40,60,240mg·kg－1 were given intragastrically (ig) in three SI treatment groups,and solvent in two control groups for 9 weeks.Results:SI could inhibit the rise of low density lipoprotEin(LDL),triacylglycerol(TG),total-cholestorol(TC) obviously of blood,induced by high fat feed in the plasma(P＜0.01),SI could raise the level of Apo A1 and decrease the level of ApoB100 of blood,SI had preventive effect on the rise of lipid peroxide induce by feed and it improved the activity of GSH-PX,SOD(P＜0.05 to P＜0.01).Conclusions:SI can decrease the hypertriglyceride,improve the abnormal oxidization caused by high fat feed,and alleviate the lesion due to peroxidation. 毕业论文 　　【Key words】soy isoflavones;hyperlipemia rat;lipid metabolism;lipid peroxides 论文代写 　　在 中国 古代，大豆称为“菽”。为豆科植物大豆Glycinemax（L.）Merr.的成熟种子，我国是大豆的故乡，据考证大豆在我国已有4600年人工种植的悠久 历史 。《神农本草经》首次记载了大豆及其药用价值，并列为“中品”[1]。中医学对大豆的评价是性味甘平，具有益气养血、健脾宽广、润燥消水的功效，可用于气血虚弱、疳积下利、消化不良、小便不利等。各种大豆制品的功能略有不同，用于益气补血时宜煮