氟伐他汀对扩张型心肌病大鼠心室重塑影响.docVIP

氟伐他汀对扩张型心肌病大鼠心室重塑影响 　【摘要】 探讨氟伐他汀对扩张型心肌病(DCM)大鼠心室重塑的影响及其机制。方法： 多柔比星腹腔注射建立DCM大鼠模型，将大鼠随机分为氟伐他汀组（F组），扩张型心肌病组(M组)和正常对照组(C组)。F组用氟伐他汀20 mg·kg-1 ·d-1灌胃，M组和C组用等量生理盐水灌胃。8周后进行心脏超声、血流动力学、组织病理学、心肌组织总抗氧化能力(TAOC)和丙二醛(MDA)浓度检测，并计算胶原容积分数(CVF)。结果： F组死亡率低于M组 (Plt;0.05)；与C组相比，M组大鼠的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室舒张末压(LVEDP)、心室相对质量、CVF和MDA均增高(Plt;0.05)，左室射血分数(LVEF)、左室缩短分数(LVFS)、左室收缩压(LVSP)、左室内压最大上升及下降速率(±dp/dtmax)和TAOC均降低(Plt;0.05)；与M组相比，F组大鼠的LVEDD，LVESD，LVEDP，CVF，MDA和心室相对质量均降低(Plt;0.05)，LVEF，LVFS，LVSP，±dp/dtmax和TAOC均升高(Plt;0.05)。结论： 氟伐他汀能够改善心室重塑和心功能，抗氧化应激作用可能是其机制之一。 【关键词】 扩张型心肌病 氟伐他 氧化应激 心室重塑 ［Abstract］ Objective: To investigate the influence of fluvastatin on ventricular remodeling in a rat model of doxorubicin induced dilated cardiomyopathy (DCM)rats and its mechanism. Methods： SD rats were administered doxorubicin intraperitoneally,then DCM rats model and nomal rats were randomly divided into the fluvastatin therapy (F)group，the dilated cardiomyopathy(M)group and the control(C)group. F group was administered fluvastatin by daily gavage at a dose of 20 mg·kg-1 d-1. M and C group were administered the same dose nomal salt water by daily gavage. After 8 weeks of therapy，cardiac function was assessed by echocardiography, hemodynamics, ventricular weight/body weight ratio, and the myocardial concentration of total antioxidation capacity (TAOC)and MDA were measured. Results： The mortality was lower in F group than in M group(Plt;0.05).Compared with the C group, LVEDD, LVESD, LVEDP, LVRW, RVRW, CVF and MDA were all increased(Plt;0.05), while LVEF, LVFS, LVSP, ±dp/dtmax, and TAOC were all decreased in the M group(Plt;0.05). In comparison with the M group, LVEDD, LVESD, LVEDP, LVRW, RVRW and MDA were all significantly decreased(Plt;0.05), while LVEF, LVFS, LVSP, ±dp/dtmaxand TAOC were all increased in the F group(Plt;0.05). Conclusion： Treatment with fluvastatin could attenuate left ventricular remodeling in a rat model of doxorubicin induced dilated cardiomyopathy, and the antioxi