a phylogenomic gene cluster resource the phylogenetically inferred groups (phigs) databasephylogenomic基因集群资源系统推断组(phigs)数据库.pdfVIP

BMC Bioinformatics BioMed Central Database Open Access A phylogenomic gene cluster resource: the Phylogenetically Inferred Groups (PhIGs) database 1 1,2 Paramvir S Dehal* and Jeffrey L Boore Address: 1Evolutionary Genomics Department, DOE Joint Genome Institute and Lawrence, Berkeley National Laboratory, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA and 2Department of Integrative Biology, 3060 Valley Life Sciences Building, University of California, Berkeley, CA 94720, USA Email: Paramvir S Dehal* - psdehal@; Jeffrey L Boore - jlboore@ * Corresponding author Published: 11 April 2006 Received: 20 April 2005 Accepted: 11 April 2006 BMC Bioinformatics 2006, 7:201 doi:10.1186/1471-2105-7-201 This article is available from: /1471-2105/7/201 © 2006 Dehal and Boore; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: We present here the PhIGs database, a phylogenomic resource for sequenced genomes. Although many methods exist for clustering gene families, very few attempt to create truly orthologous clusters sharing descent from a single ancestral gene across a range of evolutionary depths. Although these non-phylogenetic gene family clusters