a prospective study of xrcc1 (x-ray cross-complementing group 1) polymorphisms and breast cancer riskxrcc1的前瞻性研究(x射线cross-complementing组1)多态性与乳腺癌的风险.pdfVIP

Available online /content/7/6/R1168 Vol 7 No 6 Open Access Research article A prospective study of XRCC1 (X-ray cross-complementing group 1) polymorphisms and breast cancer risk Alpa V Patel, Eugenia E Calle, Alexandre L Pavluck, Heather Spencer Feigelson, Michael J Thun and Carmen Rodriguez Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30309, USA Corresponding author: Alpa V Patel, apatel@ Received: 15 Aug 2005 Revisions requested: 13 Sep 2005 Revisions received: 14 Oct 2005 Accepted: 24 Oct 2005 Published: 21 Nov 2005 Breast Cancer Research 2005, 7:R1168-R1173 (DOI 10.1186/bcr1355) This article is online at: /content/7/6/R1168 © 2005 Patel et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The gene XRCC1 (X-ray repair cross- Results We observed a significant inverse association between complementing group 1) encodes a protein involved in DNA Trp194 carriers (Trp/Trp and Trp/Arg) compared with Trp194 base excision repair. Two non-synonymous polymorphisms in non-carriers in relation to breast cancer (Arg/Arg) (odds ratio XRCC1 (Arg194Trp and Arg399Gln) have been shown to alter (OR) 0.62, 95% confidence interval (CI) 0.40 to 0.95). The DNA repair capacity in some studies in vitro. However, results inverse association between breast cancer and Trp194 carriers of previous association studies of these two XRCC1 var