原创力文档a robust linear regression based algorithm for automated evaluation of peptide identifications from shotgun proteomics by use of reversed-phase liquid chromatography retention time基于鲁棒线性回归算法自动评价猎枪的肽识别蛋白质组学利用反相液相色谱保留时间.pdfVIP
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a robust linear regression based algorithm for automated evaluation of peptide identifications from shotgun proteomics by use of reversed-phase liquid chromatography retention time基于鲁棒线性回归算法自动评价猎枪的肽识别蛋白质组学利用反相液相色谱保留时间
BMC Bioinformatics BioMed Central
Research article Open Access
A robust linear regression based algorithm for automated
evaluation of peptide identifications from shotgun proteomics by
use of reversed-phase liquid chromatography retention time
1 2 1
Hua Xu , Lanhao Yang and Michael A Freitas*
Address: 1Department of Molecular Virology Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University
Medical Center, Columbus, 43210, OH, USA and 2Department of Chemistry, the Ohio State University, Columbus, 43210, OH, USA
Email: Hua Xu - xu.171@; Lanhao Yang - yang.976@; Michael A Freitas* - freitas.5@
* Corresponding author
Published: 19 August 2008 Received: 11 March 2008
Accepted: 19 August 2008
BMC Bioinformatics 2008, 9:347 doi:10.1186/1471-2105-9-347
This article is available from: /1471-2105/9/347
© 2008 Xu et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Rejection of false positive peptide matches in database searches of shotgun
proteomic experimental data is highly desirable. Several methods have been developed to use the
peptide retention time as to refine and improve peptide identifications from database search
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