a population-based study of kurdish breast cancer in northern iraq hormone receptor and her2 status. a comparison with arabic women and united states seer data以人群为基础的研究在伊拉克北部库尔德人乳腺癌激素受体和her2状态。.pdfVIP

Majid et al. BMC Womens Health 2012, 12:16 /1472-6874/12/16 RESEARCH ARTICLE Open Access A population-based study of Kurdish breast cancer in northern Iraq: Hormone receptor and HER2 status. A comparison with Arabic women and United States SEER data 1 2 1 1 3 Runnak A Majid , Hazha A Mohammed , Hemin A Hassan , Wasan A Abdulmahdi , Rekawt M Rashid and Michael D Hughson1* Abstract Background: Hormone receptor (HR) and HER2 expression predict the therapeutic response and prognosis of breast cancer. In the Middle-East, breast cancer is diagnosed at a young age, and Arabic women are reported to have a low frequency of HR positive tumors. This study investigates HR and HER2 expression among Kurdish and Arabic women. Methods: During 2008–2010, the Sulaimaniyah Directorate of Health records identified 514 Sulaimaniyah Kurdish women, 227 Kurdish women of other Governates, and 83 Arabic women with a first diagnosis of breast cancer. The breast cancers of 432 women had immunohistochemistry (IHC) performed for estrogen and progesterone receptors (ER and PR) and HER2. Age specific and age standardized incidence rates were calculated for Sulaimaniyah Kurds. Results were compared with Egypt and with United States (US) SEER data. Results: The median patient age was 46 years and 60.4% were 50 years old. Tumors of 65.2% of women were ER +/HER2- with the rate increasing to 78.3% in patients ≥ 60 years old in proportions similar to US whites. The total annual age standardized incidence for breast cancer among Sulaimaniyah Kurds was 40.5/100,000 women, a rate similar to Egypt but much lower than the US. By HR/HER2 subtype, the highest age specific incidence rates were 16.4 and 45.4/100,000 for