原创力文档a new survival model for hyperthermic intraperitoneal chemotherapy (hipec) in tumor-bearing rats in the treatment of peritoneal carcinomatosis超热状况的新的生存模式(hipec)在肿瘤腹腔化疗大鼠治疗腹膜癌扩散.pdfVIP
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a new survival model for hyperthermic intraperitoneal chemotherapy (hipec) in tumor-bearing rats in the treatment of peritoneal carcinomatosis超热状况的新的生存模式(hipec)在肿瘤腹腔化疗大鼠治疗腹膜癌扩散
BMC Cancer BioMed Central
Research article Open Access
A new survival model for hyperthermic intraperitoneal
chemotherapy (HIPEC) in tumor-bearing rats in the treatment of
peritoneal carcinomatosis
Joerg OW Pelz*, Joerg Doerfer, Werner Hohenberger and Thomas Meyer
Address: Department of Surgery, University of Erlangen-Nuremberg, Germany
Email: Joerg OW Pelz* - joerg.pelz@chir.imed.uni-erlangen.de; Joerg Doerfer - joerg.doerfer @chir.imed.uni-erlangen.de;
Werner Hohenberger - werner.hohenberger@chir.imed.uni-erlangen.de; Thomas Meyer - thomas.meyer@chir.imed.uni-erlangen.de
* Corresponding author
Published: 30 May 2005 Received: 02 August 2004
Accepted: 30 May 2005
BMC Cancer 2005, 5:56 doi:10.1186/1471-2407-5-56
This article is available from: /1471-2407/5/56
© 2005 Pelz et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC)
improves survival in patients with peritoneal carcinomatosis of colorectal origin. Animal models are
important in the evaluation of new treatment modalities. The purpose of this study was to devise
an experimental setting which can be routinely used for the investigation of HIPEC in peritoneal
carcinomatosis.
Methods: A new peritoneal pe
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