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a population proportion approach for ranking differentially expressed genes人口比例排名差异表达基因的方法
BMC Bioinformatics BioMed Central
Methodology article Open Access
A Population Proportion approach for ranking differentially
expressed genes
Mugdha Gadgil
Address: Chemical Engineering and Process Development, National Chemical Laboratory, Pune, 411008, India
Email: Mugdha Gadgil - mc.gadgil@ncl.res.in
Published: 18 September 2008 Received: 12 June 2008
Accepted: 18 September 2008
BMC Bioinformatics 2008, 9:380 doi:10.1186/1471-2105-9-380
This article is available from: /1471-2105/9/380
© 2008 Gadgil; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: DNA microarrays are used to investigate differences in gene expression between
two or more classes of samples. Most currently used approaches compare mean expression levels
between classes and are not geared to find genes whose expression is significantly different in only
a subset of samples in a class. However, biological variability can lead to situations where key genes
are differentially expressed in only a subset of samples. To facilitate the identification of such genes,
a new method is reported.
Methods: The key difference between the Population Proportion Ranking Method (PPRM)
presented here and almost all other methods currently used is
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