a tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences基于树的保护计分法简称线性图案蛋白质序列的多重比对.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences 1 2 1 2 Claudia Chica , Alberto Labarga , Cathryn M Gould , Rodrigo López and Toby J Gibson* 1 Address: 1EMBL Structural and Computational Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany and 2EBI European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK Email: Claudia Chica - claudia.chica@embl.de; Alberto Labarga - alabarga@ebi.ac.uk; Cathryn M Gould - cathryn.gould@embl.de; Rodrigo López - rls@ebi.ac.uk; Toby J Gibson* - toby.gibson@embl.de * Corresponding author Published: 6 May 2008 Received: 14 November 2007 Accepted: 6 May 2008 BMC Bioinformatics 2008, 9:229 doi:10.1186/1471-2105-9-229 This article is available from: /1471-2105/9/229 © 2008 Chica et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and short linear motifs. The latter are involved in protein interactio