a white-box approach to microarray probe response characterization the bafl pipeline白盒方法微阵列探针响应表征bafl管道.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access A white-box approach to microarray probe response characterization: the BaFL pipeline †1 †2 3 Kevin J Thompson , Hrishikesh Deshmukh , Jeffrey L Solka and Jennifer W Weller*4 Address: 1Computer Science Dept, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA, 2Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, 63110, USA, 3Department of Bioinformatics and Computational Biology, George Mason University, Manassas, VA, 20110, USA and 4Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA Email: Kevin J Thompson - kthom110@; Hrishikesh Deshmukh - deshmukh@; Jeffrey L Solka - jlsolka@; Jennifer W Weller* - jweller2@ * Corresponding author †Equal contributors Published: 29 December 2009 Received: 26 June 2009 Accepted: 29 December 2009 BMC Bioinformatics 2009, 10:449 doi:10.1186/1471-2105-10-449 This article is available from: /1471-2105/10/449 © 2009 Thompson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Microarrays depend on appropriate probe design to deliver the promise of accurate genome-