原创力文档a structural analysis of in vitro catalytic activities of hammerhead ribozymes结构分析的体外催化锤头核糖酶的活动.pdfVIP
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a structural analysis of in vitro catalytic activities of hammerhead ribozymes结构分析的体外催化锤头核糖酶的活动
BMC Bioinformatics BioMed Central
Research article Open Access
A structural analysis of in vitro catalytic activities of hammerhead
ribozymes
† †
Yu Shao , Susan Wu , Chi Yu Chan, Jessie R Klapper, Erasmus Schneider and
Ye Ding*
Address: Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, NY 12208, USA
Email: Yu Shao - yushao04@; Susan Wu - swu@; Chi Yu Chan - chanc@;
Jessie R Klapper - jklapper@; Erasmus Schneider - schneid@; Ye Ding* - yding@
* Corresponding author †Equal contributors
Published: 30 November 2007 Received: 18 July 2007
Accepted: 30 November 2007
BMC Bioinformatics 2007, 8:469 doi:10.1186/1471-2105-8-469
This article is available from: /1471-2105/8/469
© 2007 Shao et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequence-
specific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit translation
of genes at the messenger RNA (mRNA) level in both eukaryotic and prokaryotic systems and are
thus useful tools for studies of gene function. However, identification of target sites for efficient
cleavage poses a challenge. Here, we have considered a number of structural and ther
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