原创力文档aberrant expression of cd133 protein correlates with ki-67 expression and is a prognostic marker in gastric adenocarcinoma异常的cd133的表达蛋白质与ki - 67表达和胃腺癌的预后指标.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
aberrant expression of cd133 protein correlates with ki-67 expression and is a prognostic marker in gastric adenocarcinoma异常的cd133的表达蛋白质与ki - 67表达和胃腺癌的预后指标
Zhao et al. BMC Cancer 2010, 10:218
/1471-2407/10/218
R E S E A R C H A R T I C L E Open Access
Research article
Aberrant expression of CD133 protein correlates
with Ki-67 expression and is a prognostic marker in
gastric adenocarcinoma
† † †
Po Zhao* , Yazhuo Li and Yali Lu
Abstract
Background: The relationships between the expression of CD133, Ki-67 and prognosis in gastric adenocarcinoma are
unknown and needs exploring.
Methods: The samples of gastric adenocarcinoma from 336 Chinese patients with follow-up were analyzed for CD133
and Ki-67 protein expressions by immunohistochemical method.
Results: CD133 was expressed in up to 57.4% (193/336) of this group of gastric carcinoma. The expression of CD133
was significantly higher in carcinoma than in normal (P = 0.0001) and dysplastic mucosas (P = 0.004). CD133 was
positive corresponded with the tumour size, grade, infiltrative depth and clinical stage (all P 0.05). The overall mean
survival time of the patients with CD133 positive expression was shorter than that of patients with negative expression
(P = 0.0001). The expression of CD133 has a positive correlation with that of Ki-67 (r = 0.188, P = 0.001) in gastric
adenocarcinoma. CD133 was an independent prognostic indicator. (P = 0.0001).
Conclusions: It is suggested that CD133 may play an important role in the evolution of gastric adenocarcinoma and
should be considered as a potential marker for the prognosis.
Background one marker of hematopoietic stem cells, CD133 mRNA
Gastric cancer is one of the most aggressive malignan- transcript could also be found in normal non-lymphoid
cies, with an extremely poor prognosis, and is the second hematopoietic tissue [
您可能关注的文档
- a supermatrix analysis of genomic, morphological, and paleontological data from crown cetaceasupermatrix分析基因组、形态和古生物皇冠鲸类的数据.pdf
- a survey of abnormalities in the colon and rectum in patients with haemorrhoids结肠和直肠异常的调查患者的痔核.pdf
- a surveillance sector review applied to infectious diseases at a country level监督部门审查应用于传染病在国家层面.pdf
- a subset of the diverse cog0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life多样化的一个子集cog0523家族公认的陪伴与金属锌体内平衡在生活的所有王国.pdf
- a survey of attitudes toward clinical research among physicians at kyoto university hospital临床研究的态度的调查中在京都大学医院的医生.pdf
- a survey of community members' perceptions of medical errors in oman社区成员对医疗事故的看法的调查在阿曼.pdf
- a survey of compliance medicaid's mandated blood lead screenings for children age 12–18 months in nebraska合规医疗补助的规定调查儿童血铅筛查年龄12 - 18个月内布拉斯加州.pdf
- a survey of current and past pediatric infectious diseases fellows regarding training现在和过去的调查关于培训儿科传染病研究员.pdf
- a survey of emergency department use in patients with cyclic vomiting syndrome的调查急诊科在周期性呕吐综合征患者使用.pdf
- a survey of core and support activities of communicable disease surveillance systems at operating-level cdcs in china核心的调查和支持活动的传染病监测系统在运营层面在中国疾病预防控制中心.pdf
- aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer畸变在平移监管与激素受体阳性乳腺癌预后不良有关.pdf
- aberrant stalk development and breakdown of tip dominance in dictyostelium cell lines with rnai-silenced expression of calcineurin b异常茎的开发和故障提示在盘基网柄菌与rnai-silenced细胞系的表达钙调磷酸酶b.pdf
- ability of online drug databases to assist in clinical decision-making with infectious disease therapies在线药品数据库,协助临床决策能力与传染性疾病疗法.pdf
- aberrant over-expression of a forkhead family member, foxo1a, in a brain tumor cell line异常表达的forkhead家庭成员,foxo1a脑部肿瘤细胞系.pdf
- abi3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescenceabi3异位表达降低体外和体内细胞生长特性而诱导衰老.pdf
- ablation of prion protein immunoreactivity by heating in saturated calcium hydroxide消融的朊蛋白免疫反应性通过加热饱和氢氧化钙.pdf
- aberrant host immune response induced by highly virulent prrsv identified by digital gene expression tag profiling异常的宿主免疫反应引起的高毒性prrsv被数字基因表达标记分析.pdf
- ablation lesions in koch's triangle assessed by three-dimensional myocardial contrast echocardiography消融病变科赫的三角形由三维心肌对比超声心动图评估.pdf
- ability of group ivb metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines能力组ivb茂金属司长委任聚醚含有dienestrol逮捕选择癌症细胞系的生长.pdf
- abnormal glucose regulation in patients with acute st- elevation myocardial infarction-a cohort study on 224 patients葡萄糖调节异常患者急性st -抬高心肌infarction-a队列研究224例.pdf
文档评论（0）