acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample a randomized controlled trial可接受性、有效性和成本效益网络暴露治疗肠易激综合征的临床随机对照试验样品.pdfVIP

Ljótsson et al. BMC Gastroenterology 2011, 11:110 /1471-230X/11/110 RESEARCH ARTICLE Open Access Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: a randomized controlled trial 1* 1,2 1 1 3 1 Brjánn Ljótsson , Gerhard Andersson , Erik Andersson , Erik Hedman , Perjohan Lindfors , Sergej Andréewitch , Christian Rück1 and Nils Lindefors1 Abstract Background: Internet-based cognitive behavior therapy (ICBT) has shown promising effects in the treatment of irritable bowel syndrome (IBS). However, to date no study has used a design where participants have been sampled solely from a clinical population. We aimed to investigate the acceptability, effectiveness, and cost- effectiveness of ICBT for IBS using a consecutively recruited sample from a gastroenterological clinic. Methods: Sixty-one patients were randomized to 10 weeks of ICBT (n = 30) or a waiting list control (n = 31). The ICBT was guided by an online therapist and emphasized acceptance of symptoms through exposure and mindfulness training. Severity of IBS symptoms was measured with the Gastrointestinal symptom rating scale - IBS version (GSRS-IBS). Patients in both groups were assessed at pre- and post-treatment while only the ICBT group was assessed 12 months after treatment completion. Health economic data were also gathered at all assessment points and analyzed using bootstrap sampling. Results: Fifty of 61 patients (82%) completed the post-treatment assessment and 20 of 30 patients (67%) in the ICBT group were assessed at 12-month follow-up. The ICBT group demonstrated significantly (p .001) larger improvements on the IBS-related o