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a systematic review of the diagnostic accuracy of prostate specific antigen系统回顾的前列腺特异抗原的诊断准确性.pdf

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a systematic review of the diagnostic accuracy of prostate specific antigen系统回顾的前列腺特异抗原的诊断准确性

BMC Urology BioMed Central Research article Open Access A systematic review of the diagnostic accuracy of prostate specific antigen Philip Harvey*, Amman Basuita, Deborah Endersby, Ben Curtis, Aphrodite Iacovidou and Mary Walker Address: School of Medicine, University of Birmingham, Birmingham, UK Email: Philip Harvey* - Pxh553@bham.ac.uk; Amman Basuita - Axb526@bham.ac.uk; Deborah Endersby - Dxe566@bham.ac.uk; Ben Curtis - Bxc544@bham.ac.uk; Aphrodite Iacovidou - Axi520@bham.ac.uk; Mary Walker - Mew506@bham.ac.uk * Corresponding author Published: 10 September 2009 Received: 8 April 2009 Accepted: 10 September 2009 BMC Urology 2009, 9:14 doi:10.1186/1471-2490-9-14 This article is available from: /1471-2490/9/14 © 2009 Harvey et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Prostate cancer is the fourth commonest cancer in the UK, and the incidence is rising. The reference standard for diagnosing this condition is prostate biopsy, an invasive procedure. This study systematically reviews recent literature on tPSA accuracy. The time period was restricted to ensure that the estimates referred to contemporary tPSA tests and prostate cancer reference standards. The focus of this review w