acetylation of pamam dendrimers for cellular delivery of sirna乙酰化作用的pamam树枝状分子细胞的核.pdfVIP

BMC Biotechnology BioMed Central Research article Open Access Acetylation of PAMAM dendrimers for cellular delivery of siRNA 1 2 2 Carolyn L Waite , Sarah M Sparks , Kathryn E Uhrich and Charles M Roth*1,3 Address: 1Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, USA, 2Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA and 3Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA Email: Carolyn L Waite - waitec@; Sarah M Sparks - sparkss@; Kathryn E Uhrich - uhrich@; Charles M Roth* - cmroth@ * Corresponding author Published: 23 April 2009 Received: 29 September 2008 Accepted: 23 April 2009 BMC Biotechnology 2009, 9:38 doi:10.1186/1472-6750-9-38 This article is available from: /1472-6750/9/38 © 2009 Waite et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process. In