acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of fallot case reportacute-on-chronic肝衰竭由于thiamazole甲状腺机能亢进患者,法洛三联症病例报告.pdfVIP

Shen et al. BMC Gastroenterology 2010, 10:93 /1471-230X/10/93 CASE REPORT Open Access Acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of Fallot: case report 1 1* 1 1 2 Chuan Shen , Cai-Yan Zhao , Fang Liu , Ya-Dong Wang , Jun Yu Abstract Background: Thiamazole is a widely used antithyroid agent that has been approved for the treatment of hyperthyroidism. Although thiamazole-induced hepatotoxicity is a main side effect, it may progress to liver failure in a very few cases. Case Presentation: We described a 24-year-old patient with hyperthyroidism and trilogy of Fallot, who developed liver failure due to thiamazole. Liver biopsy showed intrahepatic cholestasis, mild inflammatory infiltrates, as well as significant fibrosis, indicating both acute and chronic liver injuries. Although a series of potent therapies were given, the patient deceased due to severe liver decompensation. Conclusions: This case suggests that thiamazole-induced hepatotoxicity in the setting of advanced fibrosis increases the risk of poor outcome. Regular liver function monitoring during thiamazole therapy is therefore important. Background Here, we report the first case of a patient with Liver dysfunction is a common complication observed in hyperthyroidism and TOF that was recently referred to hyperthyroidism, either as a result of hyperthyroidism our hospital for acute-on-chronic liver failure (ACLF) and/or the use of antithyroid drugs (ADs). ADs includ- related to MMI. ing thiamazole (MMI) and propylthiouracil (PTU) are widely used for treating hyperthyroidism. Despite their