abnormal shortened diastolic time length at increasing heart rates in patients with abnormal exercise-induced increase in pulmonary artery pressure异常的舒张期缩短的时间长度在增加患者的心率异常运动性肺动脉压力增加.pdfVIP
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abnormal shortened diastolic time length at increasing heart rates in patients with abnormal exercise-induced increase in pulmonary artery pressure异常的舒张期缩短的时间长度在增加患者的心率异常运动性肺动脉压力增加
Bombardini et al. Cardiovascular Ultrasound 2011, 9:36
/content/9/1/36
CARDIOVASCULAR
ULTRASOUND
RESEARCH Open Access
Abnormal shortened diastolic time length at
increasing heart rates in patients with abnormal
exercise-induced increase in pulmonary artery
pressure
*
Tonino Bombardini , Rosa Sicari, Elisabetta Bianchini and Eugenio Picano
Abstract
Background: The degree of pulmonary hypertension is not independently related to the severity of left ventricular
systolic dysfunction but is frequently associated with diastolic filling abnormalities. The aim of this study was to
assess diastolic times at increasing heart rates in normal and in patients with and without abnormal exercise-
induced increase in pulmonary artery pressure (PASP). Methods. We enrolled 109 patients (78 males, age 62 ± 13
years) referred for exercise stress echocardiography and 16 controls. The PASP was derived from the tricuspid
Doppler tracing. A cut-off value of PASP ≥ 50 mmHg at peak stress was considered as indicative of abnormal
increase in PASP. Diastolic times and the diastolic/systolic time ratio were recorded by a precordial cutaneous force
sensor based on a linear accelerometer.
Results: At baseline, PASP was 30 ± 5 mmHg in patients and 25 ± 4 in controls. At peak stress the PASP was
normal in 95 patients (Group 1); 14 patients (Group 2) showed an abnormal increase in PASP (from 35 ± 4 to 62 ±
12 mmHg; P 0.01). At 100 bpm, an abnormal ( 1) diastolic/systolic time ratio was found in 0/16 (0%) controls, in
12/93 (13%) Group 1 and 7/14 (50%) Group 2 patients (p 0.05 between groups).
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