a survey of green plant trna 3-end processing enzyme trnase zs, homologs of the candidate prostate cancer susceptibility protein elac2绿色植物的调查trna 3 端处理酶trnase z,前列腺癌易感性蛋白质elac2同系物的候选人.pdfVIP
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a survey of green plant trna 3-end processing enzyme trnase zs, homologs of the candidate prostate cancer susceptibility protein elac2绿色植物的调查trna 3 端处理酶trnase z,前列腺癌易感性蛋白质elac2同系物的候选人
Fan et al. BMC Evolutionary Biology 2011, 11:219
/1471-2148/11/219
RESEARCH ARTICLE Open Access
A survey of green plant tRNA 3’-end processing
enzyme tRNase Zs, homologs of the candidate
prostate cancer susceptibility protein ELAC2
Lijuan Fan1,2,3, Zhikang Wang1,2,3, Jinyu Liu1,2,3, Weili Guo1,2,3, Jie Yan4 and Ying Huang1,2,3*
Abstract
Background: tRNase Z removes the 3’-trailer sequences from precursor tRNAs, which is an essential step preceding
the addition of the CCA sequence. tRNase Z exists in the short (tRNase ZS L
) and long (tRNase Z ) forms. Based on
the sequence characteristics, they can be divided into two major types: bacterial-type tRNase ZS and eukaryotic-
type tRNase ZL S
, and one minor type, Thermotoga maritima (TM)-type tRNase Z . The number of tRNase Zs is highly
variable, with the largest number being identified experimentally in the flowering plant Arabidopsis thaliana. It is
unknown whether multiple tRNase Zs found in A. thaliana is common to the plant kingdom. Also unknown is the
extent of sequence and structural conservation among tRNase Zs from the plant kingdom.
Results: We report the identification and analysis of candidate tRNase Zs in 27 fully sequenced genomes of green
plants, the great majority of which are flowering plants. It appears that green plants contain multiple distinct
tRNase Zs predicted to reside in different subcellular compartments. Furthermore, while the bacterial-type tRNase
ZS S
s are present only in basal land plants and green algae, the TM-type tRNase Z s
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