a screen for proteins that interact with pax6 c-terminal mutations disrupt interaction with homer3, dncl1 and trim11屏幕上的蛋白质与pax6 c端突变破坏与homer3互动,dncl1 trim11.pdfVIP

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a screen for proteins that interact with pax6 c-terminal mutations disrupt interaction with homer3, dncl1 and trim11屏幕上的蛋白质与pax6 c端突变破坏与homer3互动,dncl1 trim11.pdf

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a screen for proteins that interact with pax6 c-terminal mutations disrupt interaction with homer3, dncl1 and trim11屏幕上的蛋白质与pax6 c端突变破坏与homer3互动,dncl1 trim11

BMC Genetics BioMed Central Research article Open Access A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11 Simon T Cooper and Isabel M Hanson* Address: University of Edinburgh, School of Molecular and Clinical Medicine, Medical Sciences (Medical Genetics), Molecular Medicine Centre, Western General Hospital, Crewe Road Edinburgh EH4 2XU Email: Simon T Cooper - er@ed.ac.uk; Isabel M Hanson* - isabel.hanson@ * Corresponding author Published: 12 August 2005 Received: 24 January 2005 Accepted: 12 August 2005 BMC Genetics 2005, 6:43 doi:10.1186/1471-2156-6-43 This article is available from: /1471-2156/6/43 © 2005 Cooper and Hanson; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The PAX6 protein is a transcriptional regulator with a key role in ocular and neurological development. Individuals with heterozygous loss-of-function mutations in the PAX6 gene have malformations of the eye and brain. Little is known about the interactions of PAX6 with other proteins, so we carried out a systematic screen for proteins that interact with PAX6. Results: We used bioinformatics techniques to characterise a highly conserved peptide at the C- terminus of the