a profile of prognostic and molecular factors in european and māori breast cancer patients的预后和分子因素在欧洲和māori乳腺癌患者.pdfVIP

Dachs et al. BMC Cancer 2010, 10:543 /1471-2407/10/543 RESEARCH ARTICLE Open Access A profile of prognostic and molecular factors in European and Māori breast cancer patients 1* 1 1 1,2 3 4 Gabi U Dachs , Maiko Kano , Ekaterina Volkova , Helen R Morrin , Valerie CL Davey , Gavin C Harris , 4 5 1 6 1,2,7 Michelle Cheale , Christopher Frampton , Margaret J Currie , J Elisabeth Wells , Bridget A Robinson Abstract Background: New Zealand Māori have a poorer outcome from breast cancer than non-Māori, yet prognostic data are sparse. The objective of this study was to quantify levels of prognostic factors in a cohort of self-declared Māori and European breast cancer patients from Christchurch, New Zealand. Methods and Results: Clinicopathological and survival data from 337 consecutive breast cancer patients (27 Māori, 310 European) were evaluated. Fewer tumours were high grade in Māori women than European women (p = 0.027). No significant ethnic differences were detected for node status, tumour type, tumour size, human epidermal growth factor receptor, oestrogen and progesterone receptor (ER/PR) status, or survival. In addition, tumour and serum samples from a sub-cohort of 14 Māori matched to 14 NZ European patients were analyzed by immunohistochemistry and enzyme linked immunosorbent assay for molecular prognostic factors. Sig- nificant correlations were detected between increased grade and increased levels of hypoxia inducible factor-1 (HIF-1a), glucose transporter-1 (GLUT-1), microvessel density (MVD) and cytokeratins CK5/6 (p 0.05). High nodal status correlated with reduced carbon