a novel biomarker tertmrna is applicable for early detection of hepatoma一种新型生物标志物tertmrna适用于肝癌的早期检测.pdfVIP

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2017-09-11 发布于上海
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a novel biomarker tertmrna is applicable for early detection of hepatoma一种新型生物标志物tertmrna适用于肝癌的早期检测.pdf

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a novel biomarker tertmrna is applicable for early detection of hepatoma一种新型生物标志物tertmrna适用于肝癌的早期检测

Miura et al. BMC Gastroenterology 2010, 10:46 /1471-230X/10/46 R E S E A R C H A R T I C L E Open Access Research article A novel biomarker TERTmRNA is applicable for early detection of hepatoma 1 2 3 4 5 6 Norimasa Miura* , Yukio Osaki , Miki Nagashima , Michimori Kohno , Kensho Yorozu , Kohei Shomori , 7 5 7 5 8 5 Takamasa Kanbe , Kenji Oyama , Yukihiro Kishimoto , Shigeo Maruyama , Eijiro Noma , Yutaka Horie , 3 8 9 6 7 1 Masatoshi Kudo , Seigo Sakaguchi , Yasuaki Hirooka , Hisao Ito , Hironaka Kawasaki , Junichi Hasegawa and Goshi Shiota10 Abstract Backgrounds: We previously reported a highly sensitive method for serum human telomerase reverse transcriptase (hTERT) mRNA for hepatocellular carcinoma (HCC). α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are good markers for HCC. In this study, we verified the significance of hTERTmRNA in a large scale multi-centered trial, collating quantified values with clinical course. Methods: In 638 subjects including 303 patients with HCC, 89 with chronic hepatitis (CH), 45 with liver cirrhosis (LC) and 201 healthy individuals, we quantified serum hTERTmRNA using the real-time RT-PCR. We examined its sensitivity and specificity in HCC diagnosis, clinical significance, ROC curve analysis in co mparison with other tumor markers, and its correlations with the clinical parameters using Pearson relative test and multivariate analyses. Furthermore, we performed a prospective and comparative study to observe the chan