adaptive dynamics of regulatory networks size matters自适应动态监管网络规模很重要.pdfVIP

Hindawi Publishing Corporation EURASIP Journal on Bioinformatics and Systems Biology Volume 2009, Article ID 618502, 10 pages doi:10.1155/2009/618502 Research Article Adaptive Dynamics of Regulatory Networks: Size Matters 1 2 ¨ 3 Dirk Repsilber, Thomas Martinetz, and Mats Bjorklund 1 Department of Genetics and Biometry, Research Institute for the Biology of Farm Animals (FBN), Wilhelm-Stahl Allee 2, D 18196 Dummerstorf, Germany 2 Institute for Neuro- and Bioinformatics, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany ¨ ¨ 3 Department of Animal Ecology, Evolutionary Biology Centre, University of Uppsala, Norbyvagen 18 C, 75236 Uppsala, Sweden ¨ Correspondence should be addressed to Dirk Repsilber, d.repsilber@gmx.de Received 30 May 2008; Revised 3 October 2008; Accepted 16 December 2008 Recommended by Matthias Steinfath To accomplish adaptability, all living organisms are constructed of regulatory networks on different levels which are capable to differentially respond to a variety of environmental inputs. Structure of regulatory networks determines their phenotypical plasticity, that is, the degree of detail and appropriateness of regulatory replies to environmental or developmental challenges. This regulatory network structure is encoded within the genotype. Our conceptual simulation study investigates how network structure constrains the evolution of networks and their adaptive abilities. The focus is on the structural parameter network