原创力文档adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes自适应进化multiple-variable外显子和结构多样性的摘要.pdfVIP
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adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes自适应进化multiple-variable外显子和结构多样性的摘要
BMC Evolutionary Biology BioMed Central
Research article Open Access
Adaptive evolution of multiple-variable exons and structural
diversity of drug-metabolizing enzymes
Can Li and Qiang Wu*
Address: Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
Email: Can Li - canli@; Qiang Wu* - qwu@
* Corresponding author
Published: 2 May 2007 Received: 26 February 2007
Accepted: 2 May 2007
BMC Evolutionary Biology 2007, 7:69 doi:10.1186/1471-2148-7-69
This article is available from: /1471-2148/7/69
© 2007 Li and Wu; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The human genome contains a large number of gene clusters with multiple-variable-
first exons, including the drug-metabolizing UDP glucuronosyltransferase (UGT1) and I-branching
β-1,6-N-acetylglucosaminyltransferase (GCNT2, also known as IGNT) clusters, organized in a
tandem array, similar to that of the protocadherin (PCDH), immunoglobulin (IG), and T-cell
receptor (TCR) clusters. To gain insight into the evolutionary processes that may have shaped their
diversity, we performed comprehensive comparative analyses for vertebrate multiple-variable-first-
exon clusters.
Result
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