原创力文档adaptive evolution of scml1 in primates, a gene involved in male reproductionscml1适应性进化的灵长类动物,一个基因参与了男性生殖.pdfVIP
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adaptive evolution of scml1 in primates, a gene involved in male reproductionscml1适应性进化的灵长类动物,一个基因参与了男性生殖
BMC Evolutionary Biology BioMed Central
Research article Open Access
Adaptive evolution of SCML1 in primates, a gene involved in male
reproduction
Hai-hui Wu1,2,3 and Bing Su*1,2
Address: 1State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming,
Yunnan, PR China, 2Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, PR China and 3Graduate School of
Chinese Academy of Sciences, Beijing, PR China
Email: Hai-hui Wu - haihuiwu2002@; Bing Su* - sub@
* Corresponding author
Published: 5 July 2008 Received: 16 January 2008
Accepted: 5 July 2008
BMC Evolutionary Biology 2008, 8:192 doi:10.1186/1471-2148-8-192
This article is available from: /1471-2148/8/192
© 2008 Wu and Su; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Genes involved in male reproduction are often the targets of natural and/or sexual
selection. SCML1 is a recently identified X-linked gene with preferential expression in testis. To test
whether SCML1 is the target of selection in primates, we sequenced and compared the coding
region of SCML1 in major primate lineages, and we observed the signature of positive selection in
primates.
Results: We analyzed the molecular evolutionary
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