原创力文档altered gene expression in highly purified enterocytes from patients with active coeliac disease改变基因表达的高纯度肠上皮细胞活跃的腹腔疾病患者.pdfVIP
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altered gene expression in highly purified enterocytes from patients with active coeliac disease改变基因表达的高纯度肠上皮细胞活跃的腹腔疾病患者
BMC Genomics BioMed Central
Research article Open Access
Altered gene expression in highly purified enterocytes from
patients with active coeliac disease
Suzanne Bracken, Greg Byrne, Jacinta Kelly, John Jackson and
Conleth Feighery*
Address: Department of Immunology, St. Jamess Hospital, Dublin and Trinity College Dublin, Dublin Molecular Medicine Centre, Dublin,
Ireland
Email: Suzanne Bracken - Suzanne.Bracken@biotrin.ie; Greg Byrne - grbyrne@tcd.ie; Jacinta Kelly - jacinta.kelly@dit.ie;
John Jackson - jjackso2@tcd.ie; Conleth Feighery* - Con.Feighery@tcd.ie
* Corresponding author
Published: 8 August 2008 Received: 12 March 2008
Accepted: 8 August 2008
BMC Genomics 2008, 9:377 doi:10.1186/1471-2164-9-377
This article is available from: /1471-2164/9/377
© 2008 Bracken et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by
ingestion of gluten in genetically susceptible individuals. Genes within the HLA-DQ locus are
considered to contribute some 40% of the genetic influence on this disease. However, information
on other disease causing genes is sparse. Since enterocytes are considered to play a central role in
coeliac pathology, the
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