原创力文档alternative contingency table measures improve the power and detection of multifactor dimensionality reduction选择列联表措施改善多因素降维的权力和检测.pdfVIP
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alternative contingency table measures improve the power and detection of multifactor dimensionality reduction选择列联表措施改善多因素降维的权力和检测
BMC Bioinformatics BioMed Central
Research article Open Access
Alternative contingency table measures improve the power and
detection of multifactor dimensionality reduction
1 1 1 2
William S Bush , Todd L Edwards , Scott M Dudek , Brett A McKinney and
Marylyn D Ritchie*1
Address: 1Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center,
Nashville, Tennessee, USA and 2Department of Genetics, University of Alabama School of Medicine, Birmingham, Alabama, USA
Email: William S Bush - wbush@; Todd L Edwards - tedwards@;
Scott M Dudek - dudek@; Brett A McKinney - brett.mckinney@;
Marylyn D Ritchie* - ritchie@
* Corresponding author
Published: 16 May 2008 Received: 2 October 2007
Accepted: 16 May 2008
BMC Bioinformatics 2008, 9:238 doi:10.1186/1471-2105-9-238
This article is available from: /1471-2105/9/238
© 2008 Bush et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Multifactor Dimensionality Reduction (MDR) has been introduced previously as a
non-parametric statistical method for detecting gene-gene interactions. MDR performs a
dimensional reduction by assigning mu
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