altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival5 -羟色胺生理改变人类乳腺癌有利于矛盾的生长和细胞存活.pdfVIP

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altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival5 -羟色胺生理改变人类乳腺癌有利于矛盾的生长和细胞存活.pdf

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altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival5 -羟色胺生理改变人类乳腺癌有利于矛盾的生长和细胞存活

Available online /content/11/6/R81 Vol 11 No 6 Open Access Research article Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival 1,2,4 1,2 1 3 Vaibhav P Pai , Aaron M Marshall , Laura L Hernandez , Arthur R Buckley and Nelson D Horseman1,2 1Department of Molecular and Cellular Physiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA 2Systems Biology and Physiology Program, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0576, USA 3James L. Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Ave, Cincinnati, OH, 45267-0004, USA 4Current address: Tufts Center for Regenerative and Developmental Biology and Biology Department, Tufts University, 200 Boston Ave, Medford, MA, 02155, USA Corresponding author: Nelson D Horseman, nelson.horseman@ Received: 20 Jul 2009 Revisions requested: 21 Sep 2009 Revisions received: 25 Oct 2009 Accepted: 10 Nov 2009 Published: 10 Nov 2009 Breast Cancer Research 2009, 11:R81 (doi:10.1186/bcr2448) This article is online at: /content/11/6/R81 © 2009 Pai et al ; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. Abstract Introduction The breast microenvironment can either retard or Specifically, TPH1 expression undergoes a non-linear change accelerate the events associated with progression of latent