ambulatory arterial stiffness indices and target organ damage in hypertension步在高血压动脉硬化指数和靶器官损害.pdfVIP

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ambulatory arterial stiffness indices and target organ damage in hypertension步在高血压动脉硬化指数和靶器官损害.pdf

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ambulatory arterial stiffness indices and target organ damage in hypertension步在高血压动脉硬化指数和靶器官损害

Gómez-Marcos et al. BMC Cardiovascular Disorders 2012, 12:1 /1471-2261/12/1 RESEARCH ARTICLE Open Access Ambulatory arterial stiffness indices and target organ damage in hypertension 1* 1 2 Manuel Ángel Gómez-Marcos , José Ignacio Recio-Rodríguez , Ma Carmen Patino-Alonso , 1 1 1 1 Leticia Gómez-Sánchez , Cristina Agudo-Conde , Marta Gómez-Sánchez , Emiliano Rodríguez-Sánchez and Luís García-Ortiz1, for Vasorisk group Abstract Background: The present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI) - correlates best with vascular, cardiac and renal damage in hypertensive individuals. Methods: A cross-sectional study was carried out involving 258 hypertensive patients. AASI and HASI were defined as the 1-regression slope of diastolic over systolic blood pressure readings obtained from 24-hour recordings and home blood pressure over 6 days. Renal damage was evaluated by glomerular filtration rate (GFR) and microalbuminuria; vascular damage by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and ankle/ brachial index (ABI); and left ventricular hypertrophy by the Cornell voltage-duration product (VDP) and the Novacode index. Results: AASI and HASI were not correlated with microalbuminuria, however AASI and HASI- blood pressure variability ratio (BPVR) showed negative correlation with GRF. The Cornell PDV was positively correlated with AASI- BPVR-Sleep (r = 0.15, p 0.05) and the left ventricular mass index with HASI-BPVR (r = 0.19, p 0.01). Carotid IMT and PWV were positive