ahif but not hif-1α transcript is a poor prognostic marker in human breast cancerahif但不是hif-1α记录是一个可怜的人类乳腺癌预后标记.pdfVIP

Available online /content/5/6/R223 Research article Open Access aHIF but not HIF-1αα transcript is a poor prognostic marker in human breast cancer 1 2 2 1 Anne Cayre , Fabrice Rossignol , Eric Clottes and Frédérique Penault-Llorca 1Department of Pathology and INSERM U484, Centre Jean Perrin, Clermont-Ferrand, France 2Laboratoire Inter-Universitaire de Biologie des Activités Physiques et Sportives, Faculté de Médecine, Clermont-Ferrand, France Corresponding author: Anne Cayre (e-mail: anne.cayre@cjp.fr) Received: 14 Mar 2003 Revisions requested: 15 May 2003 Revisions received: 16 Jun 2003 Accepted: 28 Aug 2003 Published: 26 Sep 2003 Breast Cancer Res 2003, 5:R223-R230 (DOI 10.1186/bcr652) © 2003 Cayre et al., licensee BioMed Central Ltd (Print ISSN 1465-5411; Online ISSN 1465-542X). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Hypoxia-inducible factor-1α (HIF-1α) is part of a concentrations of HIF-1α, sHIF-1α and aHIF in 110 patients transcriptional factor that regulates genes involved in metabolic with invasive breast carcinoma. and vascular adaptation of tumours to oxygen restriction. A splicing variant lacking exon 14 (sHIF-1α) encodes a truncated Results: We found a strong positive association between protein that competes with the normal HIF-1α protein, HIF-1α and sHIF-1α, sHIF-1α and aHIF, and an invers