原创力文档adam8 in squamous cell carcinoma of the head and neck a retrospective studyadam8在头颈部鳞状细胞癌进行回顾性研究.pdfVIP
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adam8 in squamous cell carcinoma of the head and neck a retrospective studyadam8在头颈部鳞状细胞癌进行回顾性研究
Zielinski et al. BMC Cancer 2012, 12:76
/1471-2407/12/76
RESEARCH ARTICLE Open Access
ADAM8 in squamous cell carcinoma of the head
and neck: a retrospective study
1 1 1 1 2 1
Valerie Zielinski , Markus Brunner , Gregor Heiduschka , Sven Schneider , Rudolf Seemann , Boban Erovic and
Dietmar Thurnher1,3*
Abstract
Background: A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies.
ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been
found to be overexpressed in squamous cell carcinomas of the lung. A new study showed that ADAM8 is
significantly overexpressed in metastasis of squamous cell carcinomas of the head and neck (HNSCC).
Methods: We determined ADAM8 levels in the serum of 79 HNSCC patients at the time of diagnosis, in 35
patients 3 months after treatment and in 10 patients 1 year after therapy and compared the results to the sera of
31 healthy volunteers. We also constructed tissue microarrays to detect ADAM8 immunohistochemically in 100
patients. The results were correlated with the survival data of the patients to determine the diagnostic and
prognostic value.
Results: The data demonstrated that patients with high ADAM8 expression in the tumor have worse survival rates.
We found that high ADAM8 serum levels correlated with high ADAM8 expression in tumor samples. Soluble
ADAM8 levels did not show any prognostic or diagnostic properties.
Conclusion: In summary ADAM8 expression is a prognostic factor for survival of patients with head and neck
squamous cell carcinoma.
Keywords: ADAM8, Squamous cell carcinoma, Head and neck
Background
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