abnormalities in circadian blood pressure variability and endothelial function pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults内皮功能异常在昼夜血压变异性和务实的标记为不良代谢疾病概要文件在无症状的肥胖的成年人.pdfVIP

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abnormalities in circadian blood pressure variability and endothelial function pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults内皮功能异常在昼夜血压变异性和务实的标记为不良代谢疾病概要文件在无症状的肥胖的成年人.pdf

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abnormalities in circadian blood pressure variability and endothelial function pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults内皮功能异常在昼夜血压变异性和务实的标记为不良代谢疾病概要文件在无症状的肥胖的成年人

Gupta et al. Cardiovascular Diabetology 2010, 9:58 CARDIO /content/9/1/58 VASCULAR DIABETOLOGY OR I G IN A L I N VE STI G AT IO N Open Access Original investigation Abnormalities in circadian blood pressure variability and endothelial function: pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults 1 3 1 2 3 1 Alok K Gupta* , Germaine Cornelissen , Frank L Greenway , Vijay Dhoopati , Fran zHalberg and William D Johnson Abstract Background: Cardiovascular disease (CVD) risk, although perceived to be high, is often difficult to demonstrate in disease free (healthy) obese adults. Hypothesis: Changes in circadian blood pressure variability (CBPV) and endothelial function (EF) may be early correlates of cardiometabolic disorders. Methods: Asymptomatic men and women in 3 groups: normal weight (n = 10), overweight (n = 10) and obese (n = 15) were evaluated. Blood pressure and heart rate were recorded over 7 days: every 30 minutes during the day and every 60 minutes during the night, by automatic ambulatory monitoring. Resting EF was assessed in a fasting state between 8-10 AM by brachial ultrasound. Anthropometric and cardiometabolic indicators were measured and correlations with CBPV and EF were investigated. 2 Results: The 3 groups had (Mean(SD)) BMI: 22.6(1.6), 27(3) a nd 34(5) kg/m , respectively, weight: 64(16)