aminopeptidase n (apn)cd13 inhibitor, ubenimex, enhances radiation sensitivity in human cervical cancer氨肽酶n(apn)cd13抑制剂,ubenimex,提高人类宫颈癌放射敏感性.pdfVIP
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aminopeptidase n (apn)cd13 inhibitor, ubenimex, enhances radiation sensitivity in human cervical cancer氨肽酶n(apn)cd13抑制剂,ubenimex,提高人类宫颈癌放射敏感性
BMC Cancer BioMed Central
Research article Open Access
Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances
radiation sensitivity in human cervical cancer
Hirohisa Tsukamoto, Kiyosumi Shibata*, Hiroaki Kajiyama, Mikio Terauchi,
Akihiro Nawa and Fumitaka Kikkawa
Address: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Email: Hirohisa Tsukamoto - tukamoto@med.nagoya-u.ac.jp; Kiyosumi Shibata* - shiba@med.nagoya-u.ac.jp;
Hiroaki Kajiyama - kajiyama@med.nagoya-u.ac.jp; Mikio Terauchi - mikio727@med.nagoya-u.ac.jp; Akihiro Nawa - nawa2005@med.nagoya-
u.ac.jp; Fumitaka Kikkawa - kikkawaf@med.nagoya-u.ac.jp
* Corresponding author
Published: 19 March 2008 Received: 15 September 2007
Accepted: 19 March 2008
BMC Cancer 2008, 8:74 doi:10.1186/1471-2407-8-74
This article is available from: /1471-2407/8/74
© 2008 Tsukamoto et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Radiotherapy can be used to treat all stages of cervical cancer. For improving local
control via radiotherapy, it is important to use additional antitumor agents. Aminopeptidase N
(APN)/CD13, a 150-kDa metalloproteinase, is a multifunctional cell surface aminopeptidase with
ubiquitous expression. Recent studies have suggested that APN/CD13 pl
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