an integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses系统评价与管理的一个综合评估呼吸急促的呼吸系统疾病.pdfVIP

Bailey et al. BMC Pulmonary Medicine 2010, 10:63 /1471-2466/10/63 RESEARCH ARTICLE Open Access An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses 1* 1 2 2 3 2 Chris D Bailey , Richard Wagland , Rasha Dabbour , Ann Caress , Jaclyn Smith , Alex Molassiotis Abstract Background: Breathlessness is a debilitating and distressing symptom in a wide variety of diseases and still a difficult symptom to manage. An integrative review of systematic reviews of non-pharmacological and pharmacological interventions for breathlessness in non-malignant disease was undertaken to identify the current state of clinical understanding of the management of breathlessness and highlight promising interventions that merit further investigation. Methods: Systematic reviews were identified via electronic databases between July 2007 and September 2009. Reviews were included within the study if they reported research on adult participants using either a measure of breathlessness or some other measure of respiratory symptoms. Results: In total 219 systematic reviews were identified and 153 included within the final review, of these 59 addressed non-pharmacological interventions and 94 addressed pharmacological interventions. The reviews covered in excess of 2000 trials. The majority of systematic reviews were conducted on interventions for asthma and COPD, and mainly focussed upon a small number of pharmacological interventions such as corticosteroids and bronchodilators, including beta-agonists. In contrast, other conditions involving breathlessness have received little or no attention and studies continue to focus upon pharmacological approaches. Moreover, although there