原创力文档an internal ribosome entry site element directs the synthesis of the 80 kda isoforms of protein 4.1r一个内部核糖体进入网站元素指导合成的80 kda亚型蛋白4.1 r.pdfVIP
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an internal ribosome entry site element directs the synthesis of the 80 kda isoforms of protein 4.1r一个内部核糖体进入网站元素指导合成的80 kda亚型蛋白4.1 r
BMC Biology BioMed Central
Research article Open Access
An internal ribosome entry site element directs the synthesis of the
80 kDa isoforms of protein 4.1R
Eva Lospitao, Carmen M Pérez-Ferreiro, Altea Gosálbez, Miguel A Alonso and
Isabel Correas*
Address: Departamento de Biología Molecular, Universidad Autónoma de Madrid y Centro de Biología Molecular Severo Ochoa, Consejo Superior
de Investigaciones Científicas, Nicolás Cabrera, 1. Cantoblanco. E-28049 Madrid, Spain
Email: Eva Lospitao - elospitao@cbm.uam.es; Carmen M Pérez-Ferreiro - cmperez@cbm.uam.es; Altea Gosálbez - agosalbez@cbm.uam.es;
Miguel A Alonso - maalonso@cbm.uam.es; Isabel Correas* - icorreas@cbm.uam.es
* Corresponding author
Published: 4 December 2008 Received: 8 August 2008
Accepted: 4 December 2008
BMC Biology 2008, 6:51 doi:10.1186/1741-7007-6-51
This article is available from: /1741-7007/6/51
© 2008 Lospitao et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In red blood cells, protein 4.1 (4.1R) is an 80 kDa protein that stabilizes the spectrin-actin
network and anchors it to the plasma membrane through its FERM domain. While the expression pattern
of 4.1R in mature red cells is relatively simple, a rather complex array of 4.1R protein isoforms varying in
N-terminal extensions, internal sequences and subcellular
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