原创力文档an intracellular targeted antibody detects egfr as an independent prognostic factor in ovarian carcinomas一个细胞内目标抗体检测表皮生长因子受体卵巢癌作为一个独立的预后因素.pdfVIP
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an intracellular targeted antibody detects egfr as an independent prognostic factor in ovarian carcinomas一个细胞内目标抗体检测表皮生长因子受体卵巢癌作为一个独立的预后因素
Noske et al. BMC Cancer 2011, 11:294
/1471-2407/11/294
RESEARCH ARTICLE Open Access
An intracellular targeted antibody detects EGFR
as an independent prognostic factor in ovarian
carcinomas
1,2* 1 3 1 1
Aurelia Noske , Michael Schwabe , Wilko Weichert , Silvia Darb-Esfahani , Ann-Christin Buckendahl ,
4 4 1 1 1
Jalid Sehouli , Elena I Braicu , Jan Budczies , Manfred Dietel and Carsten Denkert
Abstract
Background: In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on
assessment method and data on patient outcome are conflicting. Methods: In this study we investigated EGFR
expression and its prognostic value in a cohort of 121 invasive ovarian carcinomas, using a novel antibody against
the intracellular domain of the receptor. We further evaluated an association between EGFR, the nuclear transporter
CRM1 as well as COX-2. Furthermore, we evaluated EGFR expression in ten ovarian cancer cell lines and incubated
cancer cells with Leptomycin B, a CRM1 specific inhibitor.
Results: We observed a membranous and cytoplasmic EGFR expression in 36.4% and 64% of ovarian carcinomas,
respectively. Membranous EGFR was an independent prognostic factor for poor overall survival in ovarian cancer
patients (HR 2.7, CI 1.1-6.4, p = 0.02) which was also found in the serous subtype (HR 4.6, CI 1.6-13.4, p = 0.004).
We further observed a significant association of EGFR with COX-2 and nuclear CRM1 expression (chi-square test for
trends, p = 0.006 and p = 0.013, respectively). In addition, combined membranous EGFR/COX-2 expression was
significantly related to unfavorable overall survival (HR
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