analysis and prediction of antibacterial peptides抗菌肽的分析和预测.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Analysis and prediction of antibacterial peptides Sneh Lata, BK Sharma and GPS Raghava* Address: Institute of Microbial Technology, Sector39A, Chandigarh, India Email: Sneh Lata - sneh@imtech.res.in; BK Sharma - sharma@imtech.res.in; GPS Raghava* - raghava@imtech.res.in * Corresponding author Published: 23 July 2007 Received: 20 October 2006 Accepted: 23 July 2007 BMC Bioinformatics 2007, 8:263 doi:10.1186/1471-2105-8-263 This article is available from: /1471-2105/8/263 © 2007 Lata et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Antibacterial peptides are important components of the innate immune system, used by the host to protect itself from different types of pathogenic bacteria. Over the last few decades, the search for new drugs and drug targets has prompted an interest in these antibacterial peptides. We analyzed 486 antibacterial peptides, obtained from antimicrobial peptide database APD, in order to understand the preference of amino acid residues at specific positions in these peptides. Results: It was observed that certain types of residues are preferred over others in antibacterial peptides, particularly at the N a