原创力文档an exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model一个探索的能力tepoxalin改善关节软骨的退化犬体外模型.pdfVIP
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an exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model一个探索的能力tepoxalin改善关节软骨的退化犬体外模型
BMC Veterinary Research BioMed Central
Research article Open Access
An exploration of the ability of tepoxalin to ameliorate the
degradation of articular cartilage in a canine in vitro model
Lisa Macrory, Anne Vaughan-Thomas, Peter D Clegg and John F Innes*
Address: Musculoskeletal Research Group, Faculty of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, CH64 7TE, UK
Email: Lisa Macrory - L.Macrory@liverpool.ac.uk; Anne Vaughan-Thomas - avt4460@liverpool.ac.uk; Peter D Clegg - p.d.clegg@liverpool.ac.uk;
John F Innes* - j.f.innes@liv.ac.uk
* Corresponding author
Published: 22 July 2009 Received: 29 September 2008
Accepted: 22 July 2009
BMC Veterinary Research 2009, 5:25 doi:10.1186/1746-6148-5-25
This article is available from: /1746-6148/5/25
© 2009 Macrory et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: To study the ability of tepoxalin, a dual inhibitor of cyclooxygenase (COX) and
lipoxygenase (LOX) and its active metabolite to reduce the catabolic response of cartilage to
cytokine stimulation in an in vitro model of canine osteoarthritis (OA).
Grossly normal cartilage was collected post-mortem from seven dogs that had no evidence of joint
disease. Cartilage explants were cultured in media
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