原创力文档alzpathway a comprehensive map of signaling pathways of alzheimer’s diseasealzpathway信号通路的综合地图阿尔茨海默氏症.pdfVIP
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alzpathway a comprehensive map of signaling pathways of alzheimer’s diseasealzpathway信号通路的综合地图阿尔茨海默氏症
Mizuno et al. BMC Systems Biology 2012, 6:52
/1752-0509/6/52
DATABASE Open Access
AlzPathway: a comprehensive map of signaling
pathways of Alzheimer’s disease
1† 1† 1*† 1† 2,3 2
Satoshi Mizuno , Risa Iijima , Soichi Ogishima , Masataka Kikuchi , Yukiko Matsuoka , Samik Ghosh ,
1 4 4 1
Tadashi Miyamoto , Akinori Miyashita , Ryozo Kuwano and Hiroshi Tanaka
Abstract
Background: Alzheimer’s disease (AD) is the most common cause of dementia among the elderly. To clarify
pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in
the field of AD has not been compiled as a database before.
Description: Here, we have constructed a publicly available pathway map called “AlzPathway” that
comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100
review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently
composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte,
and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology
Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web
service (online map) based on Payao system, a community-based, collaborative web service platform for pathway
model curation, enabling continuous updates by AD researchers.
Conclusions: AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways
which can
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