原创力文档analysis of frailty and survival from late middle age in the beijing longitudinal study of aging脆弱和生存分析北京中年后期的衰老的纵向研究.pdfVIP
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analysis of frailty and survival from late middle age in the beijing longitudinal study of aging脆弱和生存分析北京中年后期的衰老的纵向研究
Shi et al. BMC Geriatrics 2011, 11:17
/1471-2318/11/17
RESEARCH ARTICLE Open Access
Analysis of frailty and survival from late middle
age in the Beijing Longitudinal Study of Aging
1,2,3 3,4 2 2 3,5 2* 3,6*
Jing Shi , Xiaowei Song , Pulin Yu , Zhe Tang , Arnold Mitnitski , Xianghua Fang and Kenneth Rockwood
Abstract
Background: Frailty in individuals can be operationalized as the accumulation of health deficits, for which several
trends have been observed in Western countries. Less is known about deficit accumulation in China, the country
with the world’s largest number of older adults.
Methods: This study analyzed data from the Beijing Longitudinal Study of Aging, to evaluate the relationship
between age and deficit accumulation in men and women and to evaluate the impact of frailty on mortality.
Community dwelling people aged 55+ years at baseline (n = 3275) were followed every two to three years
between 1992 and 2000, during which time 36% died. A Frailty Index was constructed using 35 deficits, drawn
from a range of health problems, including symptoms, disabilities, disease, and psychological difficulties.
Results: Most deficits increased the eight-year risk of death and were more lethal in men than in women,
although women had a higher mean level of frailty (Frailty Index = 0.11 ± 0.10 for men, 0.14 ± 0.12 for women).
The Frailty Index increased exponentially with age, with a similar rate in men and women (0.038 vs. 0.039;
r 0.949, P 0.01). A dose-response relationship was observed as frailty increased.
Conclusions: A Frailty Index employed in a Chinese sample, showed properties comparable with Western data,
but deficit accumulation appeared to be more letha
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