an initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, cop1最初的生物化学和细胞生物学特性的哺乳动物同系物中央发育开关,cop1.pdfVIP

BMC Cell Biology BioMed Central BMC Cell Biology x 2002, Open Access 3 Research article An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1 , , , Chunling Yi , Haiyang Wang , Ning Wei and Xing Wang Deng* Address: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA E-mail: Chunling Yi - chunling.yi@; Haiyang Wang - hw75@; Ning Wei - ning.wei@; Xing Deng* - xingwang.deng@ *Corresponding author Published: 4 December 2002 Received: 11 September 2002 Accepted: 4 December 2002 BMC Cell Biology 2002, 3:30 This article is available from: /1471-2121/3/30 © 2002 Yi et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Keywords: Mammalian COP1, ubiquitination, nuclear localization/import signal (NLS), nu- clear export signal (NES), RING finger Abstract Background: Constitutive photomorphogenic 1 (COP1) has been defined as a central regulator of photomorphogenic development in plants, which targets key transcription factors for proteasome-dependent degradation. Although COP1 mammalian homologue has been previously reported, its function and distrib