analyzing mirna co-expression networks to explore tf-mirna regulation分析microrna co-expression网络探索tf-mirna监管.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Analyzing miRNA co-expression networks to explore TF-miRNA regulation Sanghamitra Bandyopadhyay and Malay Bhattacharyya* Address: Machine Intelligence Unit, Indian Statistical Institute, 203 BT Road, Kolkata, 700108, India E-mail: Sanghamitra Bandyopadhyay - sanghami@isical.ac.in; Malay Bhattacharyya* - malay_r@isical.ac.in *Corresponding author Published: 28 May 2009 Received: 14 January 2009 Accepted: 28 May 2009 BMC Bioinformatics 2009, 10:163 doi: 10.1186/1471-2105-10-163 This article is available from: /1471-2105/10/163 © 2009 Bandyopadhyay and Bhattacharyya; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Current microRNA (miRNA) research in progress has engendered rapid accumulation of expression data evolving from microarray experiments. Such experiments are generally performed over different tissues belonging to a specific species of metazoan. For disease diagnosis, microarray probes are also prepared with tissues taken from similar organs of different candidates of an organism. Expression data of miRNAs are frequently mapped to co-expression networks to study the functions of miRNAs, their regulation on genes an