antioxidative and in vitro antiproliferative activity of arctium lappa root extracts抗氧化和牛蒡根提取物体外抗增殖活动.pdfVIP

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antioxidative and in vitro antiproliferative activity of arctium lappa root extracts抗氧化和牛蒡根提取物体外抗增殖活动.pdf

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antioxidative and in vitro antiproliferative activity of arctium lappa root extracts抗氧化和牛蒡根提取物体外抗增殖活动

Predes et al. BMC Complementary and Alternative Medicine 2011, 11:25 /1472-6882/11/25 RESEARCH ARTICLE Open Access Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts 1* 2 2 1 1 Fabricia S Predes , Ana LTG Ruiz , João E Carvalho , Mary A Foglio and Heidi Dolder Abstract Background: Arctium lappa, known as burdock, is widely used in popular medicine for hypertension, gout, hepatitis and other inflammatory disorders. Pharmacological studies indicated that burdock roots have hepatoprotective, anti-inflammatory, free radical scavenging and antiproliferative activities. The aim of this study was to evaluate total phenolic content, radical scavenging activity by DPPH and in vitro antiproliferative activity of different A. lappa root extracts. Methods: Hot and room temperature dichloromethanic, ethanolic and aqueous extracts; hydroethanolic and total aqueous extract of A. lappa roots were investigated regarding radical scavenging activity by DPPH, total phenolic content by Folin-Ciocalteau method and antiproliferative in vitro activity was evaluated in human cancer cell lines. The hydroethanolic extract analyzed by high-resolution electrospray ionization mass spectroscopy. Results: Higher radical scavenging activity was found for the hydroethanolic extract. The higher phenolic contents were found for the dichloromethane, obtained both by Soxhlet and maceration extraction and hydroethanolic extracts. The HRESI-MS demonstrated the presence of arctigenin, quercetin, chlorogenic acid and caffeic acid compounds, which were identified by comparison with previous data. The dichloromethane extracts were the only extracts that exhibited activity against cancer cell lines,