原创力文档assessment of liver fibrosis and associated risk factors in hiv-infected individuals using transient elastography and serum biomarkers评估肝纤维化和相关危险因素在感染艾滋病毒的人使用瞬时弹性成像和血清生物标志物.pdfVIP
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assessment of liver fibrosis and associated risk factors in hiv-infected individuals using transient elastography and serum biomarkers评估肝纤维化和相关危险因素在感染艾滋病毒的人使用瞬时弹性成像和血清生物标志物
Vermehren et al. BMC Gastroenterology 2012, 12:27
/1471-230X/12/27
RESEARCH ARTICLE Open Access
Assessment of liver fibrosis and associated risk
factors in HIV-infected individuals using transient
elastography and serum biomarkers
1 1 2 2 2 2
Johannes Vermehren , Annika Vermehren , Axel Mueller , Amina Carlebach , Thomas Lutz , Peter Gute ,
2 1 1 1 3 1
Gaby Knecht , Christoph Sarrazin , Mireen Friedrich-Rust , Nicole Forestier , Thierry Poynard , Stefan Zeuzem ,
Eva Herrmann4 and Wolf Peter Hofmann1,5*
Abstract
Background: Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly attributable to co-
infection with hepatitis B or C. The impact of other risk factors, including prolonged exposure to combined
antiretroviral therapy (cART) is poorly understood. Our aim was to determine the prevalence of liver fibrosis and
associated risk factors in HIV-infected individuals based on non-invasive fibrosis assessment using transient
elastography (TE) and serum biomarkers (Fibrotest [FT]).
Methods: In 202 consecutive HIV-infected individuals (159 men; mean age 47 ± 9 years; 35 with hepatitis-C-virus
[HCV] co-infection), TE and FT were performed. Repeat TE examinations were conducted 1 and 2 years after study
inclusion.
Results: Significant liver fibrosis was present in 16% and 29% of patients, respectively, when assessed by TE (≥ 7.1
kPa) and FT ( 0.48). A combination of TE and FT predicted significant fibrosis in 8% of all patients (31% in HIV/
HCV co-infected and 3% in HIV mono-infected individuals). Chronic ALT, AST and g-GT elevation was present in
29%, 20% and
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