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assessment of protein set coherence using functional annotations评估使用功能注释的蛋白质组一致性
BMC Bioinformatics BioMed Central
Methodology article Open Access
Assessment of protein set coherence using functional annotations
1,2 1 2
Monica Chagoyen* , Jose M Carazo and Alberto Pascual-Montano
Address: 1Centro Nacional de Biotecnología – CSIC, Madrid, Spain and 2Dpto. Arquitectura de Computadores y Automática, Universidad
Complutense Madrid, Madrid, Spain
Email: Monica Chagoyen* - monica.chagoyen@cnb.csic.es; Jose M Carazo - carazo@cnb.csic.es; Alberto Pascual-Montano - pascual@fis.ucm.es
* Corresponding author
Published: 20 October 2008 Received: 8 July 2008
Accepted: 20 October 2008
BMC Bioinformatics 2008, 9:444 doi:10.1186/1471-2105-9-444
This article is available from: /1471-2105/9/444
© 2008 Chagoyen et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Analysis of large-scale experimental datasets frequently produces one or more sets
of proteins that are subsequently mined for functional interpretation and validation. To this end, a
number of computational methods have been devised that rely on the analysis of functional
annotations. Although current methods provide valuable
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