原创力文档assessment of the effect of phenytoin on cutaneous healing from excision of melanocytic nevi on the face and on the back苯妥英对皮肤愈合的影响的评估切除melanocytic脸上痣和背面.pdfVIP
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assessment of the effect of phenytoin on cutaneous healing from excision of melanocytic nevi on the face and on the back苯妥英对皮肤愈合的影响的评估切除melanocytic脸上痣和背面
Pereira and de A Alchorne BMC Dermatology 2010, 10:7
/1471-5945/10/7
RESEARCH ARTICLE Open Access
Assessment of the effect of phenytoin on
cutaneous healing from excision of melanocytic
nevi on the face and on the back
Carlos Augusto Zanardini Pereira1*†, Alice de Oliveira de A Alchorne2†
Abstract
Background: Topical phenytoin is a powerful skin wounds healing and it may be useful in clinical practice. The
purpose of this study was to evaluate the effect of topical phenytoin 0.5%, by comparing it with cream (control) in
wounds resulting from excision of two melanocytic nevi in the same patient. Our purpose was also to assess if
phenytoin had better therapeutic and cosmetic outcomes when compared with cream (control).
Methods: This study evaluated 100 patients with skin wounds from excision of melanocytic nevi. 50 patients with
lesions on the face and 50 patients with lesions on the back, totalizing 200 lesions excised with modified punch.
The resulting superficial skin wounds had the same diameter and depth, and second intention healing followed.
Patients were followed for 60 days. Student’s t-test, Mann Whitney nonparametric test, analysis of variance, LSD
test, Shapiro-Wilks test and Fisher test were used to analyze the results, depending on the nature of the variables
being studied.
Results: Phenytoin showed better therapeutic and cosmetic results, by healing faster, with more intense
epithelization in wounds in comparison with cream (control). Phenytoin showed a statistically significant difference
regarding the following parameters (p 0.05): wounded area and healing time. Phenytoin application resulted in a
smaller area and a shorter healing time. Also the intensity of exudates, bleeding, and the epithelization were more
intense in phenytoin-treated wounds. Regarding the shape and thickness of the scar, inj
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